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Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

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Bioactive Polymeric Nanoparticles for Periodontal Therapy.

Raquel Osorio¹, Camilo Andrés Alfonso-Rodríguez², Antonio L Medina-Castillo³

¹Dental School. University of Granada. Colegio Máximo, Campus de Cartuja s/n. 18017 Granada, Spain.

|November 8, 2016

Summary

Calcium and zinc nanoparticles show promise for periodontal disease treatment. Calcium-loaded nanoparticles promote calcium phosphate precipitation and exhibit low toxicity, offering new therapeutic strategies.

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Area of Science:

Biomaterials Science
Nanotechnology
Periodontal Medicine

Background:

Periodontal disease is a prevalent inflammatory condition affecting tooth-supporting structures.
Current treatments for periodontal disease have limitations.
Development of novel bioactive materials is crucial for effective periodontal therapy.

Purpose of the Study:

To design and evaluate calcium and zinc-loaded nanoparticles for periodontal disease treatment.
To assess the cytocompatibility and bioactivity of these nanoparticles.
To investigate the potential of these nanoparticles in promoting mineral deposition.

Main Methods:

Polymeric nanoparticles were loaded with calcium or zinc.
Calcium phosphate precipitation was assessed using scanning electron microscopy and X-ray diffraction.
Cell viability was evaluated using oral mucosa fibroblasts through DNA quantification, lactate dehydrogenase assay, and live/dead staining.

Main Results:

Calcium-loaded nanoparticles demonstrated precipitation of calcium and phosphate on their surfaces.
Non-loaded nanoparticles were non-toxic.
Calcium and zinc-loaded nanoparticles exhibited a dose-dependent but very low cytotoxic effect.

Conclusions:

Calcium-loaded nanoparticles can induce calcium phosphate precipitation, a key factor in periodontal regeneration.
The observed non-toxicity of these nanoparticles supports their potential therapeutic application.
These findings suggest novel strategies for periodontal disease treatment using engineered nanoparticles.