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Viral Hepatitis and Assisted Reproduction
1Rotunda-The Center for Human Reproduction, Mumbai, India.
Journal of Obstetrics and Gynaecology of India
|November 9, 2016
Summary
Couples undergoing infertility treatment with hepatitis B (HBV) or hepatitis C (HCV) require safety protocols to prevent transmission. Testing and specific procedures like sperm washing are crucial for safe assisted reproductive technology (ART).
Area of Science:
- Reproductive Medicine
- Infectious Diseases
- Public Health
Background:
- Infertility treatment in hepatitis-infected couples poses risks of viral transmission to partners, offspring, and laboratory personnel.
- Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections raise concerns regarding gamete/embryo contamination and potential adverse pregnancy outcomes.
Discussion:
- Management strategies for infertility in HBV/HCV-positive individuals involve stringent safety measures to prevent disease spread.
- Standard Operating Procedures (SOPs) for detection, segregation, and specialized techniques like sperm washing are vital for minimizing transmission risks.
Key Insights:
- Discordant hepatitis status within a couple presents a transmission risk, necessitating careful management.
- HBV infection can negatively impact embryo development and pregnancy, while HCV transmission via sex is low but requires sperm washing before ART.
Outlook:
- Pre-treatment screening for HIV, HBsAg, and HCV is recommended for infertile couples, especially before gamete or embryo cryopreservation.
- Implementing robust safety protocols in fertility clinics is essential for protecting virus-free individuals and materials.
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