[Chronic recurrent annular neutrophilic dermatosis]

Area of Science:

• Dermatology
• Rare diseases
• Inflammatory skin conditions

Background:

• Chronic recurrent annular neutrophilic dermatosis (CRAND) is a rare neutrophilic dermatosis.
• It is characterized by chronic annular lesions and histological findings similar to Sweet's syndrome.
• CRAND lacks systemic signs, abnormal lab values, or underlying diseases.

Observation:

• Two cases of CRAND are presented: a 41-year-old woman with lesions on her forearms and neckline, and a 38-year-old woman with lesions on her legs.
• Lesions in both cases showed histological features suggestive of Sweet's syndrome.
• Neither patient exhibited systemic inflammatory or neutrophilic conditions.

Findings:

• One patient experienced spontaneous resolution of lesions within 4 weeks.
• Hydroxychloroquine was ineffective in preventing relapse in one patient.
• Colchicine treatment led to a 10-year relapse-free period in one patient, while the other was lost to follow-up.

Implications:

• CRAND is a distinct, benign entity within the spectrum of neutrophilic dermatoses.
• Diagnosis should be considered in cases of annular lesions without systemic involvement.
• Colchicine may be an effective treatment for CRAND, warranting further investigation.