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Structural changes induced by acidic pH in human apolipoprotein B-100.

José A Fernández-Higuero1,2, Asier Benito-Vicente1,2, Aitor Etxebarria1,2

  • 1Biofisika Institute (UPV/EHU, CSIC), University of the Basque Country, UPV/EHU, Spain, Apdo. 644, 48080 Bilbao, Spain.

Scientific Reports
|November 9, 2016
PubMed
Summary

Lowers in LDL receptor (LDLR) pH induce structural changes in apolipoprotein B100 (apoB100), facilitating LDL release and degradation. These findings reveal dynamic LDL/LDLR interactions in endosomal environments.

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