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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

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Published on: August 28, 2015

Comparative evaluation of polycyanoacrylates.

Yoav Barkan¹, Mira Levinman², Ilana Veprinsky-Zuzuliya²

¹Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel; Division of Identification and Forensic Sciences, Israel Police, Jerusalem, Israel.

Acta Biomaterialia

|November 10, 2016

Summary

This summary is machine-generated.

This study compares various cyanoacrylate esters (CA) and their polymers (PolyCA), revealing how ester sidechains influence properties like degradation and mechanical strength for optimal adhesive applications.

Keywords:

Alkoxy cyanoacrylate Alkyl cyanoacrylate Cyanoacrylates Hydrolytic degradation Viscoelasticity

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Area of Science:

Polymer Chemistry
Materials Science
Biomaterials

Background:

Cyanoacrylate esters (CA) and polycyanoacrylates (PolyCA) are versatile adhesives and drug delivery systems.
Existing research primarily focuses on ethyl or 2-octyl cyanoacrylate, neglecting other ester variations.

Purpose of the Study:

To investigate and compare the synthesis, chemical characterization, hydrolytic degradation, and thermal/mechanical properties of diverse cyanoacrylate esters.
To elucidate structure-property relationships in polycyanoacrylates based on ester sidechains.

Main Methods:

Synthesis and evaluation of polycyanoacrylates from various short/long alkyl, oxy-alkyl, cyclic, and aromatic esters.
Characterization of polymer molecular weights, hydrolytic degradation rates (formaldehyde release), mechanical properties (G', G″), and glass transition temperatures (Tg).

Main Results:

All synthesized monomers formed polymers with molecular weights ranging from 15,000-150,000 Da.
Alkoxy CAs exhibited faster degradation than alkyl CAs. Octyl CA polymers showed a balance of strength and plasticity.
Alkyl CAs were brittle, while alkoxy CAs offered plasticity but lacked strength, with lower Tg values and rapid depolymerization above 200°C.

Conclusions:

Ester sidechains significantly dictate the properties of cyanoacrylate polymers.
This comparative analysis provides a foundation for selecting specific cyanoacrylate esters for targeted biomedical and forensic applications.
New polycyanoacrylate properties were characterized, expanding the scope of these biomaterials.