Platelet-derived Factor Concentrates with Hyaluronic Acid Scaffolds for Treatment of Deep Burn Wounds
Takanobu Mashiko1, Toshiharu Minabe1, Tomomi Yamakawa1
1Department of Plastic Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan; Department of Plastic Surgery, School of Medicine, University of Tokyo, Tokyo, Japan; Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan; and Department of Plastic Surgery, Jichi Medical University, Tochigi, Japan.
Abstract:
A deep burn wound is a critical condition that generally necessitates vascularized tissue coverage. We performed the injection of platelet-derived factor concentrates combined with non-cross-linked hyaluronic acid scaffolds for 2 patients with critical burn wounds with bone and tendon exposure and achieved successful healing. Hyaluronic acid was considered to have served as a controlled-release carrier of platelet-derived factors, being clinically effective for the treatment of deep burn wounds.
