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Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

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Fixed drug eruption by etoricoxib confirmed by patch test.

Aline Soares de Sousa¹, José Carlos Cardoso², Miguel Pinto Gouveia²

¹Complexo Hospitalar Padre Bento de Guarulhos - Guarulhos (SP), Brazil.

Anais Brasileiros De Dermatologia

|November 10, 2016

Summary

This summary is machine-generated.

Fixed drug eruption, often caused by non-steroidal anti-inflammatory drugs, presents as recurring lesions. A positive patch test with etoricoxib confirmed this diagnosis in a patient, aiding accurate identification.

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Area of Science:

Dermatology
Pharmacology
Clinical Medicine

Background:

Fixed drug eruption (FDE) is a specific type of adverse drug reaction characterized by recurrent, localized lesions at the same site after re-exposure to the causative agent.
Non-steroidal anti-inflammatory drugs (NSAIDs) and antibiotics are frequently implicated in FDE.
Diagnosis traditionally involves oral reintroduction, which carries risks; patch testing on residual lesional skin is a safer alternative.

Observation:

A 74-year-old female presented with multiple, round, erythematous lesions on her trunk and recurrent blistering on her right fifth finger.
These lesions appeared a few hours after initiating etoricoxib, a non-steroidal anti-inflammatory drug.
The clinical presentation was consistent with a fixed drug eruption.

Findings:

Lesional patch testing with etoricoxib yielded a positive result.
Histopathological examination of the patch test site confirmed the typical pattern of fixed drug eruption.
This case highlights the diagnostic utility of patch testing for etoricoxib-induced FDE.

Implications:

The etoricoxib patch test demonstrates specific reactivity and can reliably reproduce the characteristic histopathology of FDE.
Patch testing on lesional skin offers a valuable and safe diagnostic method for fixed drug eruptions.
This approach aids in identifying causative agents like etoricoxib, preventing future adverse reactions.