Related Experiment Video
Updated: Mar 12, 2026

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
Published on: October 3, 2019
Fixed drug eruption by etoricoxib confirmed by patch test
Aline Soares de Sousa1, José Carlos Cardoso2, Miguel Pinto Gouveia2
1Complexo Hospitalar Padre Bento de Guarulhos - Guarulhos (SP), Brazil.
Abstract:
Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. We describe the case of a 74-year-old woman with numerous, rounded, erythematous lesions on the trunk and recurrent blistering on the fifth right-hand finger, which developed a few hours after taking etoricoxib. Lesional patch testing with etoricoxib was positive and reproduced the typical pattern of a fixed drug eruption upon histopathology. We emphasize the specific reactivity of the etoricoxib patch test, and the capacity to reproduce the histologic pattern of the reaction.
Related Concept Videos
Drug Toxicity: Allergic Reactions
Allergic Drug Reactions
Drug toxicity: Idiosyncratic Reactions
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Allergic Reactions
Hypersensitivity Reactions: Immune-Complex Reactions

