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Published on: April 12, 2024
Prognostic value of GLUT-1 expression in oral squamous cell carcinoma: A prisma-compliant meta-analysis
Chen-Xi Li1, Jia-Lin Sun, Zhong-Cheng Gong
1Department of Oral and Maxillofacial Oncology Surgery, Stomatological Medical Center, The First Affiliated Hospital of Xinjiang Medical University School of Public Health, Xinjiang Medical University Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Autonomous Region, China.
Background:
A variety of studies have evaluated the correlation between glucose transporter-1 (GLUT-1) expression and prognosis of oral squamous cell carcinoma (OSCC); however, the results were inconsistent and inconclusive. A meta-analysis was performed to assess the prognostic significance of GLUT-1 in OSCC.
Methods:
Electronic databases of PubMed, Embase, and Web of Science were searched for relevant studies. The last search was updated on July 2016. Odds ratio (OR) and 95% confidence interval (CI) were pooled to evaluate the relationship between GLUT-1 and clinical features and hazard ratio (HR) and 95% CI were combined to measure the effect of GLUT-1 on overall survival (OS). P value < 0.05 was considered as statistically significant.
Results:
A total of 13 studies with 1301 subjects were included for meta-analysis. The pooled data showed that high GLUT-1 expression was associated with advanced tumor stages (n = 7, OR = 2.99, 95% CI: 2.01-4.46, P < 0.001), higher tumor grade (n = 5, OR = 3.34, 95%CI: 1.12-9.94, P = 0.031), tumor size (n = 5, OR = 3.36, 95%CI: 2.04-5.51, P < 0.001), lymph node metastasis (n = 5, OR = 3.15, 95%CI: 1.89-5.25, P < 0.001), tobacco use (n = 3, OR = 2.18, 95%CI: 1.18-4.01, P = 0.013), and distant metastasis (n = 2, OR = 3.06, 95%CI: 1.19-7.9, P = 0.02). Furthermore, increased GLUT-1 expression was also correlated with shorter OS (n = 8, HR = 1.88, 95%CI: 1.51-2.33, P < 0.001). No significant publication bias was detected in this meta-analysis.
Conclusion:
GLUT-1 overexpression was in connection with aggressive clinical features and worse OS in OSCC. However, further studies are still needed to verify whether GLUT-1 could serve as a prognostic biomarker for OSCC.
