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Acute pain management in symptomatic cholelithiasis
Tahir Masudi1, Helen Capitelli-McMahon1, Suhail Anwar1
1Tahir Masudi, Helen Capitelli-McMahon, Suhail Anwar, York Hospitals NHS Foundation Trust, the York Teaching Hospital, North Yorkshire YO31 8HE, United Kingdom.
World Journal of Gastrointestinal Surgery
|November 11, 2016
Summary
Non-steroidal anti-inflammatory drugs (NSAIDs) are effective for managing biliary colic pain and improving disease progression. Evidence shows NSAIDs offer superior symptom control with fewer doses and longer action compared to other analgesics.
Area of Science:
- Gastroenterology
- Pharmacology
- Pain Management
Background:
- Biliary colic, often caused by gallstones, presents a significant management challenge.
- Current pain management protocols for biliary colic are not well-established.
Purpose of the Study:
- To review the evidence supporting the use of non-steroidal anti-inflammatory drugs (NSAIDs) for biliary colic treatment.
- To assess the efficacy of NSAIDs in symptom control and disease progression.
Main Methods:
- An extensive literature review was conducted across major electronic databases (PubMed, Science Direct, Medline, Cochrane).
- Searched terms included "Biliary colic", "management of biliary colic", "non-steroidal anti-inflammatory drugs", "cholelithiasis".
- Included six randomized controlled trials, one non-randomized trial, and one meta-analysis from the past 15 years.
Main Results:
- Non-steroidal anti-inflammatory drugs (NSAIDs) demonstrate potent efficacy in managing biliary colic pain and influencing disease progression.
- Intravenous tenoxicam and injectable flurbiprofen show effectiveness comparable to diclofenac and ketorolac.
- NSAIDs offer superior analgesic effects due to a lower required dosage and a longer duration of action compared to alternative agents.
Conclusions:
- Non-steroidal anti-inflammatory drugs (NSAIDs) are safe and effective for alleviating pain associated with biliary colic.
- The use of NSAIDs in managing biliary colic can decrease the probability of developing further complications.
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