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Related Experiment Video

Updated: Mar 12, 2026

A Toxicological and Ecotoxicological Assay Based on Mussel (Mytilus galloprovincialis) Hemocytes Motility
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A mussel tissue certified reference material for multiple phycotoxins. Part 4: certification.

Pearse McCarron1, Elliott Wright2, Håkan Emteborg3

  • 1Measurement Science and Standards, National Research Council Canada, 1411 Oxford Street, Halifax, Nova Scotia, B3H 3Z1, Canada. pearse.mccarron@nrc-cnrc.gc.ca.

Analytical and Bioanalytical Chemistry
|November 11, 2016
PubMed
Summary
This summary is machine-generated.

A new certified reference material (CRM-FDMT1) for mussel tissue has been developed, offering certified values for multiple shellfish toxins. This material aids in the quality assurance of phycotoxin monitoring and analytical method validation.

Keywords:
AzaspiracidCRM-FDMT1DinophysistoxinDomoic acidMytilus edulisOkadaic acidPectenotoxinSpirolideYessotoxin

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Area of Science:

  • Marine Biology
  • Analytical Chemistry
  • Food Safety

Background:

  • Shellfish contamination by marine algal toxins poses a significant public health risk.
  • Accurate quantification of diverse shellfish toxins requires reliable reference materials for method validation and quality control.

Purpose of the Study:

  • To produce and certify a freeze-dried mussel tissue (Mytilus edulis) reference material (CRM-FDMT1) for multiple shellfish toxins.
  • To establish certified mass fraction values and uncertainties for 10 analytes across six toxin groups.

Main Methods:

  • Production and testing of a freeze-dried mussel tissue reference material (CRM-FDMT1).
  • Optimization of extraction procedures and liquid chromatography-based analytical methods.
  • Compensation for matrix effects in liquid chromatography-mass spectrometry using standard addition, dilution, or matrix-matched calibration.

Main Results:

  • Certified mass fraction values (mg/kg) were assigned for azaspiracids, okadaic acid, dinophysistoxins, yessotoxin, pectenotoxin-2, 13-desmethylspirolide-C, and domoic acid.
  • Combined uncertainties incorporated contributions from homogeneity, stability, and characterization.
  • CRM-FDMT1 demonstrated commutability with wet tissue homogenates.

Conclusions:

  • CRM-FDMT1 is the first shellfish matrix CRM certified for multiple toxin groups, including yessotoxins, pectenotoxins, and spirolides.
  • This reference material is crucial for quality assurance in phycotoxin monitoring programs.
  • CRM-FDMT1 supports the development and validation of analytical methods for algal toxins in seafood.