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Published on: August 7, 2017
Effect of prenatal antioxidant intake on infants' respiratory infection is modified by a CD14 polymorphism
Seo Ah Hong1, Eun Lee2, Sung Ok Kwon3
1ASEAN Institute for Health Development, Mahidol University, Salaya, Phutthamonthon, Nakhonpathom, Thailand.
Insights
Prenatal antioxidant intake may protect infants from respiratory tract infections (RTIs). This protective effect is influenced by specific genetic variations in immunity genes like CD14, TLR4, and GSDMB.
Area of Science:
- Environmental influences on child health
- Nutritional epidemiology
- Immunogenetics
Background:
- Prenatal maternal diet impacts offspring disease susceptibility, particularly with specific genetic predispositions.
- Immunity gene polymorphisms may interact with prenatal nutrition to affect infant health outcomes.
Purpose of the Study:
- To investigate the interaction between prenatal antioxidant intake and specific immunity gene polymorphisms (CD14, TLR4, GSDMB) on infant respiratory tract infection (RTI) susceptibility at 12 months.
- To determine if maternal diet during pregnancy influences RTI risk in infants based on their genetic makeup.
Main Methods:
- Analysis of 550 infants from the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort.
- Assessment of prenatal maternal diet using a food frequency questionnaire.
- Genotyping of infant cord blood for CD14 (rs2569190), TLR4 (rs1927911), and GSDMB (rs4794820) polymorphisms.
Main Results:
- Higher prenatal intake of fruits and vegetables (FV) correlated with decreased RTI risk.
- Specific genotypes (e.g., TT at rs2569190) showed reduced RTI risk with higher prenatal vitamin A, C, and FV intake.
- Interactions were observed between prenatal antioxidant intake and polymorphisms in CD14, TLR4, and GSDMB, modifying RTI risk.
Conclusions:
- Prenatal antioxidant intake may offer protection against infant RTIs.
- The relationship between prenatal antioxidant intake and RTI risk is significantly modified by CD14, TLR4, and GSDMB gene polymorphisms.
Background:
Prenatal maternal diet may influence disease susceptibility in offspring with specific genetic backgrounds. We hypothesized that interactions between prenatal antioxidant intake and polymorphisms in immunity genes influence respiratory tract infection (RTI) susceptibility in infants at 12 months of age.
Methods:
This study included 550 infants. In the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort study, prenatal maternal diet was assessed by administering a food frequency questionnaire. Infants' cord blood was genotyped for CD14 (rs2569190), TLR4 (rs1927911), and GSDMB (rs4794820) polymorphisms by the TaqMan method.
Results:
Higher prenatal intake of total fruit and vegetables (FV) was associated with the decreased risk of RTI in offspring (P-trend=0.0430). In children with TT genotype at rs2569190, a higher prenatal intake of vitamins A and C, fruits, and total FV decreased RTI risk (P-trend <0.05), while in infants with TC+CC genotype, a higher prenatal intake of fruit increased RTI risk (P-trend <0.05). When analyzing the 3 genotypes, children with TT genotype at rs2569190 were more protected against RTIs compared with those with CC genotype with respect to vitamin C and fruits [odds ratio (OR)=5.04 and OR=10.30, respectively]. In children with CC genotype at rs1927911, RTI risk showed a dose-response association with a higher prenatal intake of vitamin C (P for interaction<0.05). A higher prenatal intake of fruits and total FV reduced RTI risk in infants with GA+AA genotype of rs4794820 (P for interaction<0.05).
Conclusions:
Prenatal antioxidant intake may reduce RTI risk in infants and this relationship may be modified by CD14, TLR4, and GSDMB polymorphisms.
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