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Heart Development, Angiogenesis, and Blood-Brain Barrier Function Is Modulated by Adhesion GPCRs

Gentian Musa1, Felix B Engel2, Colin Niaudet3

  • 1Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schwabachanlage 12, Erlangen, 91054, Germany.

Handbook of Experimental Pharmacology
|November 11, 2016
PubMed

Insights

Adhesion G protein-coupled receptors (aGPCRs) are crucial for heart development and vascular angiogenesis. This review summarizes their impact on cardiovascular system formation and function.

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Cell Biology

Background:

  • The cardiovascular system is a hierarchical network of endothelial and mural cells essential for organismal hemostasis.
  • Blood circulation facilitates gas diffusion, nutrient distribution, and cell trafficking.
  • Adhesion G protein-coupled receptors (aGPCRs) are implicated in various cellular processes.

Purpose of the Study:

  • To summarize current knowledge on the role of aGPCRs in heart development.
  • To review the function of aGPCRs in modulating vascular angiogenesis.

Main Methods:

  • Literature review of studies on aGPCRs and cardiovascular development.
  • Synthesis of findings on aGPCRs in heart formation and vascular growth.

Main Results:

  • aGPCRs play a significant role in the intricate process of heart development.
  • aGPCRs are key modulators of vascular angiogenesis, influencing blood vessel formation.

Conclusions:

  • aGPCRs are critical regulators of cardiovascular development and vascularization.
  • Further research into aGPCRs could reveal new therapeutic targets for cardiovascular diseases.

Keywords:
Adhesion GPCRsAngiogenesisBlood-brain-barrierCardiovascularEndotheliumHeart developmentTrabeculation

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