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Heart Development, Angiogenesis, and Blood-Brain Barrier Function Is Modulated by Adhesion GPCRs
Gentian Musa1, Felix B Engel2, Colin Niaudet3
1Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schwabachanlage 12, Erlangen, 91054, Germany.
Handbook of Experimental Pharmacology
|November 11, 2016
Summary
Adhesion G protein-coupled receptors (aGPCRs) are crucial for heart development and vascular angiogenesis. This review summarizes their impact on cardiovascular system formation and function.
Area of Science:
- Cardiovascular Biology
- Molecular Biology
- Cell Biology
Background:
- The cardiovascular system is a hierarchical network of endothelial and mural cells essential for organismal hemostasis.
- Blood circulation facilitates gas diffusion, nutrient distribution, and cell trafficking.
- Adhesion G protein-coupled receptors (aGPCRs) are implicated in various cellular processes.
Purpose of the Study:
- To summarize current knowledge on the role of aGPCRs in heart development.
- To review the function of aGPCRs in modulating vascular angiogenesis.
Main Methods:
- Literature review of studies on aGPCRs and cardiovascular development.
- Synthesis of findings on aGPCRs in heart formation and vascular growth.
Main Results:
- aGPCRs play a significant role in the intricate process of heart development.
- aGPCRs are key modulators of vascular angiogenesis, influencing blood vessel formation.
Conclusions:
- aGPCRs are critical regulators of cardiovascular development and vascularization.
- Further research into aGPCRs could reveal new therapeutic targets for cardiovascular diseases.
Keywords:
Adhesion GPCRsAngiogenesisBlood-brain-barrierCardiovascularEndotheliumHeart developmentTrabeculationMore Related Videos
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