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Updated: Mar 12, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Production and application of menaquinone-7 (vitamin K2): a new perspective
Ehsan Mahdinia1, Ali Demirci1, Aydin Berenjian2
1Department of Agricultural and Biological Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Abstract:
Menaquinone-7, a highly valuable member of the vitamin K series, has significant effects on preventing osteoporosis and cardiovascular disease besides its positive effects on blood coagulation. In this review, chemical and biological aspects of menaquinone-7 are briefly summarized followed by a critical review on upstream and downstream processing developments for its production and recovery, including solid versus liquid fermentations, static versus agitated fermentations and online versus post-production recovery. Latest research outcomes for improving industrial scale production of menaquinone-7 are summarized and recommendations are given for areas of future research.
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