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Advances in analytical methodologies to guide bioprocess engineering for bio-therapeutics

Radka Saldova1, Michelle Kilcoyne2, Henning Stöckmann1

  • 1NIBRT GlycoScience Group, The National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Dublin 4, Ireland.

Methods (San Diego, Calif.)
|November 12, 2016
PubMed
Summary

This study monitored recombinant antibody glycoforms in CHO cells using high-throughput methods. Glycosylation analysis revealed significant time-dependent decreases in sialylation and branching.

Keywords:
Bioprocess engineeringCHO cellsGlycosylationHILICLectin microarraysUPLC

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