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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Desmosomes01:05

Desmosomes

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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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Related Experiment Video

Updated: Mar 12, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Dermal plexiform spindle cell lipoma.

José Fernando Val-Bernal1, Sandra Hermana

  • 1Pathology Unit, Department of Medical and Surgical Sciences, University of Cantabria, Santander, Spain; apavbj@humv.es.

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|November 12, 2016
PubMed
Summary

A rare dermal plexiform spindle cell lipoma, characterized by a myxoid matrix, is presented. This study details a unique case and reviews existing literature on this uncommon skin tumor.

Area of Science:

  • Dermatopathology
  • Oncology
  • Surgical Pathology

Background:

  • Spindle cell lipoma (SCL) is a benign mesenchymal tumor typically found in the subcutis.
  • The dermal location of SCL is uncommon, and the plexiform variant is exceedingly rare, with limited prior case reports.

Observation:

  • A case of a 47-year-old male with a 2.2 cm dermal mass on the right buttock is described.
  • Histological examination revealed a mixture of mature adipocytes, spindle cells, and myxoid stroma with a plexiform pattern.
  • Immunohistochemistry showed spindle cell positivity for CD34, factor XIIIa, and vimentin.

Findings:

  • This report adds a seventh case to the literature of dermal plexiform SCL, highlighting its prominent myxoid matrix.
  • Immunophenotype of spindle cells supports a fibroblastic/myofibroblastic or possibly adipocytic lineage, distinct from neural markers.

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  • Review of seven cases indicates a predilection for the thigh-groin-buttock area and a female predominance.

    • Implications:

    • This case expands the understanding of the morphological spectrum and rare presentations of spindle cell lipoma.
    • Accurate diagnosis is crucial, with differential considerations including dermal intraneural plexiform neurofibroma and plexiform spindle cell nevus.
    • Further research may elucidate the specific pathogenesis and clinical behavior of this rare variant.