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Inhibiting macrophage PI3Kγ to enhance immunotherapy
Wei Zheng1, Jeffrey W Pollard1,2
1Department of Developmental and Molecular Biology, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Cell Research
|November 12, 2016
Abstract
None:
A recent paper published in Nature reports that the immunosuppressive activity of tumor-associated macrophages is regulated via PI3Kγ signaling. Small-molecule inhibitors targeting PI3Kγ stimulate T cell activity against tumor alone and add additional effects for clinically proven PD1 immunotherapy.
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