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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Gene-expression profiling to predict responsiveness to immunotherapy.

N B Jamieson1,2, A V Maker3

  • 1Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences and the Academic Unit of Surgery, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland.

Cancer Gene Therapy
|November 12, 2016
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Summary
This summary is machine-generated.

Tumor gene-expression profiling (GEP) can predict responses to cancer immunotherapy. Understanding genetic markers aids in selecting personalized treatment strategies and identifying new therapeutic opportunities.

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Area of Science:

  • Oncology
  • Genomics
  • Immunology

Background:

  • Immunotherapy has shown clinical success in cancer treatment, leading to broader applications.
  • Precision immunotherapy requires matching strategies to patient and tumor genetic profiles.

Purpose of the Study:

  • To explore the role of tumor gene-expression profiling (GEP) in predicting immunotherapy response.
  • To review genetic markers associated with immunotherapy response, resistance, and relapse.

Main Methods:

  • Analysis of genetic markers related to the tumor genomic landscape.
  • Evaluation of markers including DNA damage extent, tumor mutational load, and neoantigens.
  • Review of genetic markers linked to resistance to checkpoint blockade and cancer relapse.

Main Results:

  • Gene-expression profiling (GEP) is a key tool for predicting immunotherapy outcomes.
  • Specific genetic markers correlate with response, resistance, and relapse.
  • GEP can identify novel tumor types suitable for immunotherapy.

Conclusions:

  • Genomic-driven precision immunotherapy is essential for enhancing antitumor responses.
  • GEP facilitates personalized treatment selection and the development of combinatorial strategies.
  • Further research into GEP will optimize immunotherapy efficacy and expand its application.