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Updated: Mar 12, 2026
Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis
Published on: June 2, 2022
Neuronal surface antibodies in HIV-infected patients with isolated psychosis
Vanessa Cunill1, Susana Arboleya2, Maria de Los Reyes Jiménez1
1Department of Immunology, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain; Institut d'Investigacio Sanitaria de Palma (IdISPa), Spain.
Abstract:
Neuronal surface antibodies (NSA) involved in autoimmune encephalitis (AE) have been related to relapses in HVS encephalitis. Their role in non-encephalitic psychosis is controversial. We previously reported an HIV-infected patient, NSA-positive, only presenting psychosis. Therefore, we determined the NSA prevalence in a prospective cohort of 22 HIV-positive patients with psychosis and we analyzed the frequency of HIV infection among NSA tested patients due to AE suspicion. We found no NSA in the prospective cohort. In the retrospective analysis, 22% of NSA-positive versus 4.6% of negative patients were HIV-positive. Wider studies are required to clarify the relationship between NSA and HIV infection.
