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[Breast cancer and diabetes mellitus: Complex interactions]
L Bernard1, N Reix2, J-C Benabu1
1Unité de sénologie, hôpital Haute-pierre, hôpitaux universitaires de Strasbourg, CHRU, 1, avenue Molière, 67200 Strasbourg, France.
Gynecologie, Obstetrique & Fertilite
|November 13, 2016
Summary
Women with diabetes have a significantly increased incidence and mortality of breast cancer. This highlights the need for lifestyle modifications and regular screenings for diabetic women.
Area of Science:
- Endocrinology
- Oncology
- Epidemiology
Background:
- Diabetes mellitus and breast cancer are prevalent diseases with complex interrelations.
- Understanding the epidemiological link is crucial for patient management and public health.
Purpose of the Study:
- To quantify breast cancer incidence and mortality in women with diabetes mellitus.
- To analyze the intricate relationship between diabetes and breast cancer.
Main Methods:
- A systematic literature review and meta-analysis of 22 case/control studies and cohorts.
- Data were extracted from the PubMed database (2000-2015).
Main Results:
- Breast cancer incidence is significantly increased in women with diabetes (RR=1.32 in cohorts).
- Breast cancer mortality is significantly higher in diabetic patients (RR=1.53).
- Shared risk factors, biological mechanisms, and treatments contribute to this association.
Conclusions:
- Physicians should optimize anti-diabetic treatment and promote lifestyle changes in breast cancer patients with diabetes.
- Diabetic women should engage in regular breast cancer screenings and clinical examinations.
Keywords:
Breast cancer riskDiabète de type 2IncidenceMellitus diabetesMeta-analysisMortalityMortalitéMéta-analyseRisque de cancer du seinMore Related Videos
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