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Updated: Mar 12, 2026

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome
Published on: September 19, 2019
[Wells syndrome mimicking facial cellulitis: Three cases]
C Gallard1, S Law-Ping-Man1, L Darrieux1
1Service de dermatologie, centre hospitalier de Saint-Brieuc, 10, rue Marcel-Proust, 22000 Saint-Brieuc, France.
Wells syndrome, or eosinophilic cellulitis, can mimic bacterial facial cellulitis. Early consideration and treatment with antihistamines and corticosteroids can lead to rapid improvement and prevent relapse.
Area of Science:
- Dermatology
- Inflammatory Dermatoses
Background:
- Wells syndrome (eosinophilic cellulitis) is a rare inflammatory skin condition.
- It presents as itchy, cellulitis-like plaques, typically on extremities.
- Histology shows eosinophilic infiltrate and "flame figures".
Observation:
- Three cases of idiopathic Wells syndrome mimicking bacterial facial cellulitis are presented.
- Patients received oral prednisone and/or combined levocetirizine and hydroxyzine therapy.
- All patients demonstrated significant improvement in skin lesions.
Findings:
- Wells syndrome should be considered in facial cellulitis cases unresponsive to antibiotics.
- Combined therapy with levocetirizine and hydroxyzine shows promise.
- This combination may serve as a first-line treatment or for relapse prevention.
Implications:
- Highlights the importance of differential diagnosis in facial skin conditions.
- Suggests novel therapeutic strategies for Wells syndrome.
- Improves patient outcomes by enabling timely and appropriate treatment.
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