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Congenital Hypothyroidism and Bone Remodeling Cycle

Nazmi Mutlu Karakaş1, Sibel Tulgar Kınık, Beril Özdemir

  • 1Başkent University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey, Phone: +90 530 3301977 E-mail: drmutlukarakas@hotmail.com, nmkarakas@baskent.edu.tr.

Journal of Clinical Research in Pediatric Endocrinology
|November 15, 2016
PubMed

Insights

Children with congenital hypothyroidism on thyroxine replacement therapy showed normal bone turnover markers. Effective vitamin D and thyroxine treatment ensure congenital hypothyroidism is not detrimental to bone health.

Area of Science:

  • Pediatric Endocrinology
  • Bone Metabolism
  • Biochemistry

Background:

  • Congenital hypothyroidism (CH) requires lifelong thyroid hormone replacement.
  • Bone health in treated CH patients needs evaluation.
  • Biochemical markers can assess bone turnover.

Purpose of the Study:

  • To compare bone turnover markers in children with CH undergoing treatment versus healthy controls.
  • To assess the impact of long-term treatment on bone metabolism in CH.

Main Methods:

  • Included 31 children with CH and 29 healthy controls.
  • Measured serum procollagen type-1 N-terminal propeptide (PINP) and tartrate-resistant acid phosphatase type 5b isoform (TRACP 5b).
  • Evaluated thyroid hormone and vitamin D levels.

Main Results:

  • Thyroid hormone levels were normal in both groups.
  • Vitamin D levels were higher in the CH group.
  • No significant difference in PINP; TRACP 5b (osteoclast activity marker) was higher in controls.

Conclusions:

  • Long-term levothyroxine (LT4) treatment did not increase bone resorption in CH patients.
  • Effective vitamin D and thyroxine replacement appear protective for bone turnover in CH.
  • Congenital hypothyroidism, when treated, may not be a negative factor for bone health.
Abstract

Keywords:
Congenital hypothyroidismbone marker thyroxin.

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