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Updated: Mar 12, 2026
11:23
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
Published on: October 6, 2019
10.8K
Mathematical modeling and synthetic biology
D Chandran1, W B Copeland1, S C Sleight1
1Department of Bioengineering, University of Washington, William H. Foege Building, Box 355061, Room N210E, Seattle, WA 98195-5061, USA.
Drug Discovery Today. Disease Models
|November 15, 2016
Summary
Synthetic biology uses engineering and molecular biology to program microbes for new functions. Combining modeling and experimental methods enables engineered microbes as a powerful technological platform.
Area of Science:
- Synthetic biology
- Molecular biology
- Bioengineering
Background:
- Synthetic biology leverages mechanistic understanding of molecular biology.
- Programming microbes requires integrating mechanistic insights with engineering principles.
Purpose of the Study:
- To highlight the synergistic relationship between modeling and experimental techniques in synthetic biology.
- To underscore the potential of engineered microbes as a versatile technological platform.
Main Methods:
- Utilizing computational modeling to design and predict the behavior of biological circuits.
- Employing experimental techniques to merge models with real biological systems.
- Integrating quantitative data with a library of biological 'parts' for circuit construction.
Main Results:
- Demonstrated the successful integration of modeling and experimental approaches.
- Validated the predictability of cellular functions through engineered biological circuits.
- Showcased the utility of biological parts for constructing novel genetic circuits.
Conclusions:
- The combined use of modeling and experimental methods is crucial for advancing synthetic biology.
- Engineered microbes represent a viable and powerful technological platform for diverse applications.
- Predictable manipulation of cellular functions is achievable through synthetic biology principles.
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