Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

323
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
323
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

114
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
114
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

99
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
99
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

88
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
88
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

103
Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
103
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

1.3K
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating evolutionary and compositional features with ML and DL for robust and interpretable druggable protein prediction.

Journal of computer-aided molecular design·2026
Same author

Leveraging blockchain with zero knowledge proofs in wearable health technologies for personalized healthcare.

Scientific reports·2025
Same author

The Association of Intra-Abdominal Adhesions with Peritoneal Dialysis Catheter-Related Complications.

Clinical journal of the American Society of Nephrology : CJASN·2024
Same author

Leprosy with type 1 reaction in a patient from Ontario, Canada without recent travel misdiagnosed as vasculitic neuropathy: a case report.

BMC infectious diseases·2023
Same author

A T cell-targeted multi-antigen vaccine generates robust cellular and humoral immunity against SARS-CoV-2 infection.

Molecular therapy. Methods & clinical development·2023
Same author

Cutaneous candidiasis mimicking acute generalized exanthematous pustulosis: A case report.

SAGE open medical case reports·2023
Same journal

Exercise-Induced Rhabdomyolysis With Markedly Elevated Creatine Kinase and Preserved Renal Function.

Case reports in nephrology·2026
Same journal

The Common Collagen of Alport Syndrome and Arthritis: A Case Report and Review of Pathophysiology.

Case reports in nephrology·2026
Same journal

Liddle Syndrome Presenting as Hypertensive Crisis and Myocardial Injury in a Young Male: A Case Report.

Case reports in nephrology·2026
Same journal

Dual Aetiology of Diabetes Insipidus in Pregnancy: Vasopressinase-Mediated and Central Mechanisms.

Case reports in nephrology·2026
Same journal

A Novel NPHS1-Associated Phenotype Characterized by Recurrent Transient Proteinuria.

Case reports in nephrology·2026
Same journal

Gitelman Syndrome in a Child Presenting With Polyuria and Polydipsia: Diagnostic Challenges in a Resource-Limited Setting.

Case reports in nephrology·2026
See all related articles

Related Experiment Video

Updated: Mar 12, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

7.8K

Systemic Toxicity of Intraperitoneal Vancomycin.

Teerath Kumar1, Iris Teo2, Brendan B McCormick1

  • 1Division of Nephrology, Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada; Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada.

Case Reports in Nephrology
|November 15, 2016
PubMed
Summary
This summary is machine-generated.

Intraperitoneal vancomycin, used for dialysis peritonitis, can cause rare systemic toxicity. This case study details the first instance of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome linked to this treatment.

More Related Videos

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.9K
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

13.4K

Related Experiment Videos

Last Updated: Mar 12, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

7.8K
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.9K
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

13.4K

Area of Science:

  • Nephrology
  • Pharmacology
  • Toxicology

Background:

  • Intraperitoneal vancomycin is a standard empiric treatment for peritoneal dialysis peritonitis.
  • High systemic concentrations are often achieved with intermittent dosing, yet systemic toxicity is rarely reported.
  • Peritoneal dialysis patients are susceptible to infections requiring effective antibiotic management.

Purpose of the Study:

  • To report the first case of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with intraperitoneal vancomycin.
  • To review existing literature on systemic toxicity from intraperitoneal vancomycin.
  • To raise awareness of potential severe adverse drug reactions in peritoneal dialysis patients.

Main Methods:

  • A case report of a patient developing DRESS syndrome after three weeks of intraperitoneal vancomycin treatment.
  • Comprehensive literature review of adverse events related to intraperitoneal vancomycin.
  • Clinical assessment and diagnostic criteria for DRESS syndrome.

Main Results:

  • The patient developed DRESS syndrome, a severe systemic drug reaction, after receiving intraperitoneal vancomycin.
  • Literature search revealed no prior documented cases of DRESS syndrome from intraperitoneal vancomycin.
  • This represents the first reported instance of this specific adverse drug reaction.

Conclusions:

  • Intraperitoneal vancomycin, despite its common use, can lead to severe systemic toxicity like DRESS syndrome.
  • Clinicians should be vigilant for signs of DRESS syndrome in patients undergoing peritoneal dialysis and treated with vancomycin.
  • Further investigation into the mechanisms and incidence of vancomycin-induced DRESS syndrome in this population is warranted.