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Lipids and Adipokines in Cord Blood and at 72 h in Discordant Dichorionic Twins
Svetlana Milenković1, Borisav Jankovic2,3, Ljiljana Mirković3,4
1a Clinic for Gynecology and Obstetrics , Neonatology, Clinical Center of Serbia , Belgrade , Serbia.
Background:
Intrauterine growth restriction (IUGR) is a risk factor for developing metabolic syndrome later in life. We explored whether adipokine concentrations in cord blood (CB) and on day 3 (D3) were related to impaired fetal growth and lipids in IUGR twins.
Patients And Methods:
Thirty-six discordant (birth weight [BW] discordance ≥20% calculated in relation to the heavier co-twins) and 42 concordant (BW discordance ≤ 10%) twin pairs were included.
Results:
In IUGR twins, both adiponectin/BW and triglyceride (TG) levels were significantly higher, while total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol were lower in CB. On D3, both leptin and HDL-C levels were significantly lower and TG levels were significantly higher in IUGR twins. In the discordant group, the alterations in lipids were not related to any adipokine.
Conclusions:
IUGR is related to lower leptin level and proatherogenic lipid profile (higher TG and lower HDL-C), which are not influenced by adipokine at birth.
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