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Updated: Mar 12, 2026
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
23.7K
Sinonasal methicillin-resistant Staphylococcus aureus: updates on treatment
Fahad Al-Asousi1, Anali Dadgostar, Amin Javer
1St. Paul's Sinus Centre, Department of Surgery, University of British Columbia, Vancouver, Canada.
Current Opinion in Otolaryngology & Head and Neck Surgery
|November 15, 2016
Summary
Managing methicillin-resistant Staphylococcus aureus (MRSA) in chronic rhinosinusitis is challenging. Promising new treatments include topical antibiotics and nonantibiotic therapies like photodynamic therapy and colloidal silver.
Area of Science:
- Otolaryngology
- Infectious Diseases
- Microbiology
Background:
- Chronic rhinosinusitis (CRS) management is complicated by methicillin-resistant Staphylococcus aureus (MRSA).
- Sinonasal MRSA infections are associated with recalcitrant disease, posing significant clinical challenges.
- Traditional antibiotic approaches have yielded unsatisfactory outcomes for MRSA CRS.
Purpose of the Study:
- To review current management strategies for sinonasal MRSA infections.
- To explore novel treatment modalities for MRSA-related chronic rhinosinusitis.
- To highlight the importance of understanding emerging nonantibiotic treatments.
Main Methods:
- Literature review of current and emerging treatments for sinonasal MRSA.
- Analysis of topical antibiotic therapies (ofloxacin, mupirocin).
- Evaluation of nonantibiotic modalities (antimicrobial photodynamic therapy, colloidal silver).
Main Results:
- Topical ofloxacin drops and mupirocin ointments show beneficial results for MRSA chronic sinusitis (off-label use).
- Emerging nonantibiotic options, including antimicrobial photodynamic therapy and colloidal silver irrigation, demonstrate promising outcomes.
- Systemic and local antibiotic advancements have been slow and insufficient.
Conclusions:
- MRSA is a significant factor in difficult-to-treat chronic rhinosinusitis.
- The shift towards nonantibiotic antibacterial treatments is critical for improving patient outcomes.
- Clinicians must be aware of novel therapeutic options for effective MRSA sinonasal infection management.
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