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Contamination of germfree animals with intestinal Crohn tissue. A preliminary report
Acta Chirurgica Scandinavica. Supplementum
|January 1, 1978
Abstract:
The preliminary results of one of a series of prospective studies in the investigation of a possible transmissible agent in Crohn's disease are presented. Filtered human Crohn tissue homogenates was inoculated into eight germfree Sprague-Dawley rats, to test the reproducibility of recent reports suggesting a transmissible agent in regional ileitis. No histological changes were evident after 150 days, and no changes were observed in animals inoculated with non-Crohn tissue homogenates.