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Methicillin resistance and beta-lactamase production in Staphylococcus aureus
F J de Villiers1, F Huygens, A J van Rensburg
1Department of Medical Microbiology, University of Pretoria.
Abstract:
Staphylococcus aureus isolates were either sensitive, resistant or partially resistant (minimum inhibitory concentration 90 of 4 micrograms/ml) to methicillin. Low-level methicillin resistance was shown to be due to beta-lactamase production. The clinical significance of this beta-lactamase-mediated resistance is still unclear, so it is recommended that these strains should, at present, be regarded as methicillin-resistant.