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Taurolidine in Pediatric Home Parenteral Nutrition Patients

Emma Claire Hulshof1, Lidwien Marieke Hanff, Joanne Olieman

  • 1From the *Department of Hospital Pharmacy, Erasmus MC, Sophia Children's Hospital, Rotterdam, the Netherlands; †Department of Dietetics, Erasmus MC, Sophia Children's Hospital, Rotterdam, the Netherlands; ‡Department of Paediatric Surgery, Erasmus MC, Sophia Children's Hospital, Rotterdam, the Netherlands; §Department of Infectious Disease and Immunology, Erasmus MC, Sophia Children's Hospital, Rotterdam, the Netherlands; and ¶Department of Paediatric Gastroenterology, Erasmus MC, Sophia Children's Hospital, Rotterdam, the Netherlands.

The Pediatric Infectious Disease Journal
|November 16, 2016
PubMed

Insights

Taurolidine significantly reduced catheter-related bloodstream infections in home parenteral nutrition patients. Infections dropped from 12.7 to 4.3 per 1000 catheter days after taurolidine use.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • Catheter-related bloodstream infections (CRBSIs) pose a significant risk to patients requiring home parenteral nutrition (HPN).
  • Preventing CRBSIs is crucial for patient safety and reducing healthcare costs.

Purpose of the Study:

  • To evaluate the effectiveness of taurolidine in reducing CRBSIs among HPN patients.
  • To assess the impact of taurolidine implementation on infection rates in a pediatric hospital setting.

Main Methods:

  • A retrospective analysis was conducted at Sophia Children's Hospital.
  • Data on CRBSI incidence were collected before and after the introduction of taurolidine in 2011.
  • Incidence was measured per 1000 catheter days.

Main Results:

  • The incidence of CRBSIs decreased from 12.7 per 1000 catheter days before taurolidine use to 4.3 per 1000 catheter days after its introduction.
  • This represents a statistically significant reduction (relative risk = 0.36, P = 0.018).
  • The study included 7 patients.

Conclusions:

  • Taurolidine is an effective antimicrobial agent for reducing CRBSIs in HPN patients.
  • Implementing taurolidine can significantly improve patient outcomes and safety in HPN therapy.
  • Further research may explore optimal taurolidine protocols for different patient populations.

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