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Osteosarcoma: Accurately diagnosing this bone-chilling disease.

Chelsea Hiller1, Jennifer L Wegler, Christopher P Forest

  • 1Chelsea Hiller practices family medicine at the Scripps Clinic in San Diego, Calif. Jennifer L. Wegler is a clinical instructor of family medicine in the PA program at the University of Southern California in Alhambra, Calif., and practices orthopedics at Kaiser-Permanente in Baldwin Park, Calif. Christopher P. Forest is an assistant professor of clinical family medicine and director of research at the University of Southern California's Keck School of Medicine and practices urgent care and family medicine in Los Angeles, Calif. The authors have disclosed no potential conflicts of interest, financial or otherwise.

JAAPA : Official Journal of the American Academy of Physician Assistants
|November 16, 2016
PubMed
Summary

Osteosarcoma, a common childhood bone cancer, is often misdiagnosed due to its low incidence and presentation as benign pain. Early recognition of persistent bone pain, especially with weight-bearing, is crucial for timely osteosarcoma diagnosis in children.

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Area of Science:

  • Pediatric Oncology
  • Skeletal Malignancies

Background:

  • Osteosarcoma is the most frequent primary bone cancer in children and adolescents.
  • Low incidence and presentation in active individuals can lead to misdiagnosis as benign conditions, delaying treatment.

Purpose of the Study:

  • To outline the common presenting symptoms and initial radiographic findings of osteosarcoma.
  • To identify risk factors and frequently encountered misdiagnoses for pediatric osteosarcoma.
  • To emphasize clinical suspicion for osteosarcoma in young patients with persistent bone pain.

Main Methods:

  • Review of clinical presentations of osteosarcoma.
  • Analysis of initial radiographic findings.
  • Identification of risk factors and common misdiagnoses.

Main Results:

  • Frequent presenting complaints and initial radiographic signs of osteosarcoma are described.
  • Key risk factors and common misdiagnoses are highlighted.
  • The importance of considering osteosarcoma in cases of persistent bone pain, particularly with weight-bearing, is emphasized.

Conclusions:

  • Persistent bone pain, especially when associated with weight-bearing, warrants consideration of osteosarcoma in pediatric patients.
  • Awareness of osteosarcoma's typical presentations and potential for misdiagnosis is vital for clinicians.
  • Timely diagnosis of osteosarcoma can be improved by considering this malignancy in the differential diagnosis of pediatric bone pain.