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ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5

Hui-Lung Sun1, Ri Cui2, JianKang Zhou3

  • 1Department of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210, USA; Pharmacological Institute, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.

Cancer Cell
|November 16, 2016
PubMed
Summary

ERK signaling suppresses microRNA export by phosphorylating exportin-5 (XPO5), impacting liver cancer progression and drug resistance. This mechanism reveals a new role for ERK in microRNA biogenesis and offers potential therapeutic targets.

Keywords:
ERKExportin-5Pin1drug resistanceglobal downregulationliver cancermiR-122miRNAmicrotubulenuclear export

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