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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

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Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
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Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Total Internal Reflection Fluorescence Microscopy01:05

Total Internal Reflection Fluorescence Microscopy

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Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.
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Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

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Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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Doppler Optical Coherence Tomography of Retinal Circulation
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Doppler Optical Coherence Tomography of Retinal Circulation

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Novel perspectives on swept-source optical coherence tomography.

Fabio Lavinsky1, Daniel Lavinsky2

  • 1Department of Ophthalmology, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo, São Paulo, Brazil ; Department of Ophthalmology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil ; Department of Ophthalmology, Instituto de Oftalmologia Lavinsky, Rua Quintino Bocaiuva 673, Porto Alegre, RS 90410-140 Brazil.

International Journal of Retina and Vitreous
|November 17, 2016
PubMed
Summary
This summary is machine-generated.

Advanced swept-source optical coherence tomography (SS-OCT) enhances diagnosis and understanding of diverse retinal diseases. This multimodal imaging technology offers deeper insights into vitreoretinal and choroidal pathologies.

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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Multimodal digital imaging significantly improves diagnosis and understanding of vitreoretinal diseases.
  • Optical coherence tomography (OCT) is essential for managing and monitoring retinal pathologies.
  • OCT technology has advanced from time-domain to spectral-domain and now to swept-source OCT (SS-OCT).

Approach:

  • SS-OCT offers enhanced imaging depth and speed, enabling novel algorithms and features.
  • Key advancements include vitreous/vitreoretinal interface evaluation, choroid segmentation, OCT angiography, and En-face OCT.
  • A multimodal approach integrating SS-OCT is crucial for comprehensive analysis.

Key Points:

  • SS-OCT facilitates a deeper understanding of age-related macular degeneration, diabetic maculopathy, central serous chorioretinopathy, pachychoroid spectrum diseases, and macular telangiectasia.
  • It improves the documentation and understanding of surgical vitreoretinal diseases like vitreo-macular traction syndrome, epiretinal membrane, and retinal detachment.
  • SS-OCT is also valuable for evaluating glaucoma, uveitis, tumors, and anterior segment pathologies.

Conclusions:

  • SS-OCT represents a significant technological advancement in ophthalmic imaging.
  • Its multimodal capabilities are poised to revolutionize the study and management of a wide array of retinal and ocular conditions.
  • This technology enhances diagnostic accuracy and knowledge of disease mechanisms and treatment responses.