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Chronic glomerulonephritis: inflammatory mediators stimulate the collagen synthesis in glomerular epithelial cells
G M Hänsch1, I Torbohm, K Rother
1Institute of Immunology, University of Heidelberg, FRG.
International Archives of Allergy and Applied Immunology
|January 1, 1989
Abstract:
C5b-9 membrane attack complexes of complement (MAC) stimulate the production of type IV collagen in cultures of human glomerular epithelial cells. Together with other known effects of MAC interaction with glomerular cells, the complex is ascribed a role in the progress of acute glomerulitis into the chronic nephritic state.