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Bilirubin Levels are Associated With Contrast-Induced Nephropathy in Peripheral Artery Disease

Ertan Vuruşkan1, Erhan Saraçoğlu1

  • 11 Department of Cardiology, Dr Ersin Arslan Education and Research Hospital, Gaziantep, Turkey.

Angiology
|November 18, 2016
PubMed

Insights

Low serum bilirubin levels are linked to contrast-induced nephropathy (CIN) in peripheral artery disease (PAD) patients. This finding highlights bilirubin

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following radiocontrast administration.
  • Oxidative stress is implicated in CIN pathogenesis.
  • Serum bilirubin's antioxidant properties suggest a potential role in mitigating CIN.

Purpose of the Study:

  • To investigate the association between serum total bilirubin levels and the development of CIN in patients with peripheral artery disease (PAD).
  • To evaluate serum bilirubin as a potential biomarker for predicting CIN risk.

Main Methods:

  • Retrospective study of 359 patients with PAD undergoing peripheral diagnostic angiography.
  • Comparison of 179 patients who developed CIN with 180 matched control patients.
  • Analysis of baseline and follow-up laboratory values, including total bilirubin, uric acid, and neutrophil-to-lymphocyte ratio (NLR).

Main Results:

  • Patients who developed CIN had significantly lower baseline total bilirubin levels compared to controls (P < .05).
  • Higher uric acid, red cell distribution width, and NLR were also associated with CIN.
  • Multivariate analysis identified decreased total bilirubin, diabetes mellitus, reduced left ventricular ejection fraction, elevated uric acid, and increased NLR as independent predictors of CIN.

Conclusions:

  • Decreased serum total bilirubin is associated with an increased risk of developing CIN in PAD patients.
  • Serum bilirubin may serve as a valuable antioxidant biomarker for predicting CIN.
  • Further research is warranted to explore therapeutic strategies targeting bilirubin levels to prevent CIN.

Keywords:
bilirubincontrast-induced nephropathyperipheral artery disease

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