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Diffuse Alveolar Hemorrhage Associated with Makyo-kanseki-to Administration
Yuko Iida1, Yuki Takano, Yusaku Ishiwatari
1Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Japan.
Internal Medicine (Tokyo, Japan)
|November 18, 2016
Summary
This case report details diffuse alveolar hemorrhage (DAH) in a patient treated with Makyo-kanseki-to, a Chinese herbal medicine. The condition resolved after discontinuing the herbal drug, suggesting a causal link.
Area of Science:
- Pharmacology
- Pulmonology
- Herbal Medicine
Background:
- A 64-year-old male with bronchial asthma presented with persistent cough.
- Makyo-kanseki-to, a traditional Chinese herbal drug, was initiated as an adjunctive therapy for asthma management.
Observation:
- The patient experienced immediate expectoration of bloody sputum shortly after ingesting Makyo-kanseki-to.
- Clinical presentation included bilateral ground-glass opacities on chest CT and bloody bronchoalveolar lavage fluid.
Findings:
- A diagnosis of diffuse alveolar hemorrhage (DAH) was established.
- The temporal relationship between Makyo-kanseki-to administration and symptom onset, along with resolution upon drug cessation, strongly implicated the herbal medication.
Implications:
- This case highlights a potential adverse effect of Makyo-kanseki-to, specifically DAH.
- Clinicians should consider herbal medications as potential causes of iatrogenic conditions, even in patients with pre-existing respiratory diseases.
