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Updated: Mar 12, 2026
OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
Published on: February 5, 2020
Organogel-assisted topochemical synthesis of multivalent glyco-polymer for high-affinity lectin binding
Baiju P Krishnan1, Sreedevi Raghu1, Somnath Mukherjee1
1School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala 695016, India. kms@iisertvm.ac.in.
Abstract:
An organogelator, 2,4-undeca-diynyl-4',6'-O-benzylidene-β-d-galactopyranoside, which aligns its diacetylene upon gelation, has been synthesized. UV irradiation of its gel resulted in topochemical polymerization of the gelator forming polydiacetylene (PDA). We have used this gel-state reaction for the synthesis of surface-immobilized multi-valent glycoclusters, which showed 1000-fold enhanced binding, compared to monomers, with various galactose-binding lectins.
