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Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics

Yiqing Zhou1, Weichao Li2, Xixi Zhang3

  • 1CAS Key Laboratory of Synthetic Biology, CAS Centre for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China. ylxiao@sibs.ac.cn.

Chemical Communications (Cambridge, England)
|November 18, 2016
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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...