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Implantation of stimulation electrodes in the subretinal space to demonstrate cortical responses in Yucatan minipig in the course of visual prosthesis development.

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Intraocular pressure during lamellar cuts with two different microkeratomes.

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Related Experiment Video

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A Step by Step Protocol for Subretinal Surgery in Rabbits
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[The Subretinal Implant - Clinical Results].

H G Sachs1

  • 1Augenklinik, Krankenhaus Dresden-Friedrichstadt, Dresden.

Klinische Monatsblatter Fur Augenheilkunde
|November 18, 2016
PubMed
Summary

Subretinal electronic chips offer vision restoration for degenerative retinal diseases. Retinal-based concepts, particularly subretinal stimulation, show promise by potentially utilizing eye movements for object detection.

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Neuroscience

Background:

  • Subretinal electronic chips have been utilized since the late 20th century to restore vision in patients with degenerative retinal diseases like retinitis pigmentosa.
  • Various international scientific groups have proposed different surgical procedures for vision restoration.

Purpose of the Study:

  • To compare the efficacy and physiological concepts of distinct retina-based vision restoration strategies.
  • To investigate the potential benefits of subretinal stimulation, including the utilization of eye movements for object detection.

Main Methods:

  • Review of existing human data on retinal-based vision restoration concepts.
  • Comparison of epiretinal (camera-based) and subretinal stimulation approaches.

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  • Emphasis on the need for well-designed human studies with adequate patient numbers.

    • Main Results:

    • Retinal-based concepts, particularly subretinal access, differ physiologically from camera-based systems (epiretinal, transchoroidal).
    • Subretinal access may allow for the use of eye movements in object detection, a feature absent in camera-based systems.
    • The clinical relevance of eye movement utilization for visual perception remains to be determined.

    Conclusions:

    • Carefully designed human studies with sufficient patient numbers are crucial to answer key questions regarding subretinal chip efficacy.
    • Comparing visual outcomes across different research groups presents significant challenges.
    • Successful implantation requires highly skilled and trained retinal surgeons.