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Related Concept Videos

Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Related Experiment Video

Updated: Mar 11, 2026

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
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Regional brain structural abnormality in ischemic stroke patients: a voxel-based morphometry study.

Ping Wu1, Yu-Mei Zhou1, Fang Zeng1

  • 1Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.

Neural Regeneration Research
|November 19, 2016
PubMed
Summary
This summary is machine-generated.

Structural brain changes in ischemic stroke patients were identified using MRI. Gray matter density alterations in specific regions correlated with motor and functional deficits, aiding in objective abnormality detection.

Keywords:
Fugl-Meyer Motor Assessmentbrain structure abnormalityfunctional deficiencyfunctional magnetic resonance imaginggray matter densityischemic strokenerve regenerationnervous functional deficiency scaleneural regenerationneural reorganizationneuroplasticityvoxel-based morphometry

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Area of Science:

  • Neuroimaging
  • Neurology
  • Stroke Research

Background:

  • Previous research indicated altered brain activity in ischemic stroke patients using regional homogeneity analysis.
  • Structural changes accompanying these functional alterations require further investigation.

Purpose of the Study:

  • To investigate structural brain changes in patients with ischemic stroke.
  • To correlate gray matter density alterations with clinical assessments.

Main Methods:

  • Structural magnetic resonance imaging (sMRI) scans were acquired from 11 ischemic stroke patients and 15 healthy controls.
  • Voxel-based morphometry (VBM) was employed to analyze differences in gray matter density.
  • Correlations between gray matter density and clinical scales (Fugl-Meyer Motor Assessment, nervous functional deficiency scale) were examined.

Main Results:

  • Ischemic stroke patients showed increased gray matter density in the left inferior occipital gyrus and right anterior white matter tract compared to controls.
  • Reduced gray matter density was observed in the right cerebellum, left precentral gyrus, right middle frontal gyrus, and left middle temporal gyrus.
  • Gray matter density in the middle frontal gyrus negatively correlated with motor function (r = -0.609, P = 0.047).
  • Gray matter density in the left middle temporal gyrus negatively correlated with nervous system functional deficiency (r = -0.737, P = 0.010).

Conclusions:

  • Voxel-based morphometry reveals significant structural gray matter differences in the brains of ischemic stroke patients.
  • These structural changes are associated with motor and neurological functional deficits.
  • Findings provide objective markers for identifying functional abnormalities in ischemic stroke.