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Modulation of pulmonary artery contraction by endothelium-derived relaxing factor
T Yamaguchi1, D Rodman, R O'Brien
1CVP Research Laboratory, University of Colorado Health Sciences Center, Denver 80262.
European Journal of Pharmacology
|February 28, 1989
Abstract:
In isolated rat pulmonary artery rings, both endothelial denudation and treatment with 10(-5) M hemoglobin inhibited relaxation to acetylcholine and increased contractile sensitivities, i.e. decreased the EC50s, to KCl, angiotensin II and norepinephrine. Denudation caused similar inhibition of acetylcholine relaxation and potentiation of KCl and norepinephrine contractions in isolated bovine pulmonary arteries. These results indicate that endothelium-derived relaxing factor plays a significant role in modulating the contractile sensitivity of isolated pulmonary arteries to at least some agonists.