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Updated: Mar 11, 2026

Design and Validation of a Volumetric-extrusion Bioprinter for Bioprinting of Soluble Basement Membrane Extract for Translational Research
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Rapid Continuous Multimaterial Extrusion Bioprinting.

Wanjun Liu1,2,3, Yu Shrike Zhang1,2,4, Marcel A Heinrich1,2,5

  • 1Biomaterials Innovation Research Center, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.

Advanced Materials (Deerfield Beach, Fla.)
|November 19, 2016
PubMed
Summary
This summary is machine-generated.

A new multimaterial extrusion bioprinting platform enables rapid fabrication of complex constructs. This advanced system precisely deposits multiple bioinks continuously from a single printhead for enhanced tissue engineering applications.

Keywords:
bioinksbioprintinghydrogelsmultimaterialtissue engineering

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Area of Science:

  • Biotechnology
  • Materials Science
  • Regenerative Medicine

Background:

  • Bioprinting technologies are crucial for creating complex biological structures.
  • Current platforms often face limitations in handling multiple bioinks efficiently.
  • The demand for advanced fabrication methods in tissue engineering is rapidly growing.

Purpose of the Study:

  • To develop and report a novel multimaterial extrusion bioprinting platform.
  • To enable continuous deposition and rapid switching of multiple bioinks.
  • To facilitate the fabrication of intricate biological constructs.

Main Methods:

  • Utilized a digitally controlled extrusion system with a single printhead containing bundled capillaries.
  • Implemented a motorized stage with programmed movement for precise bioink deposition.
  • Developed a system for fast and smooth switching between multiple bioink reservoirs.

Main Results:

  • Successfully developed a multimaterial extrusion bioprinting platform.
  • Demonstrated continuous deposition of multiple coded bioinks.
  • Achieved rapid fabrication of complex constructs through efficient bioink switching.

Conclusions:

  • The developed platform offers a significant advancement in multimaterial bioprinting.
  • This technology enables faster and more precise fabrication of complex tissue constructs.
  • The platform holds potential for diverse applications in tissue engineering and regenerative medicine.