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Updated: Mar 11, 2026
Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells
Published on: October 13, 2023
Novel approaches to early detection of endometrial cancer
Madhu Bagaria1, Emily Shields, Jamie N Bakkum-Gamez
1aDepartment of Obstetrics and Gynecology, Mayo Clinic Health System, Austin bDepartment of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA.
Purpose Of Review:
Detection of endometrial cancer at an early stage leads to better oncologic outcomes. To date, a screening test for endometrial cancer does not exist.
Recent Findings:
Evolving knowledge of molecular changes involved in endometrial cancer carcinogenesis paired with sensitive and high-throughput technological advancements are a promising combination that can be leveraged to detect tumor DNA and proteins. These molecular biomarkers can be identified in biospecimens collected via minimally invasive and noninvasive approaches. Exploiting lower genital tract secretions as a biospecimen also allows for patient self-sampling.
Summary:
Successful development of a screening test for endometrial cancer using self-collected lower genital tract biospecimens has the potential to increase accessibility to care and improve patient compliance.
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