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Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications
Stefan Wuttke1, Andreas Zimpel1, Thomas Bein1
1Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), 81377, Munich, Germany.
Advanced Healthcare Materials
|November 19, 2016
Summary
Metal-organic frameworks (MOFs) show potential for medical uses, but their safety varies by cell type. Comprehensive nanosafety evaluations are crucial for MOF nanoparticles in drug delivery and implants.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Toxicology
Background:
- Metal-organic frameworks (MOFs) offer tunable properties for nanomedical applications.
- Understanding the health risks of novel nanomaterials is essential before clinical use.
Purpose of the Study:
- To comprehensively analyze the nanosafety of different MOF nanoparticles for diverse medical applications.
- To evaluate MOF suitability for drug delivery, dental implant coatings, and nerve guidance tubes.
Main Methods:
- Assessed MOF effects on human endothelial and mouse lung cells.
- Validated MOFs for dental implant coatings using human gingiva fibroblasts.
- Evaluated MOF biocompatibility for nerve guidance tubes with human Schwann cells and rat dorsal root ganglion cultures.
Main Results:
- Nanosafety and suitability of MOF nanoparticles varied significantly depending on the interacting cell type.
- MOFs demonstrated differential effects on endothelial, lung, gingiva fibroblast, Schwann, and neuronal cells.
Conclusions:
- The nanosafety of MOF nanomaterials is highly dependent on the specific medical application and the interacting primary cell types.
- Careful, application-specific nanosafety evaluations are necessary for the clinical translation of MOF-based nanomedicines.
