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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
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Precision Medicine and PET/Computed Tomography: Challenges and Implementation.

Rathan M Subramaniam1

  • 1Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Department of Biomedical Engineering, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA.

PET Clinics
|November 20, 2016
PubMed
Summary
This summary is machine-generated.

Precision medicine matches therapies to patients using molecular targets. Positron Emission Tomography/computed tomography (PET/CT) addresses challenges in precision oncology, improving patient selection and therapy assessment.

Keywords:
BiomarkerPET/computed tomographyPatient selectionPrecision medicine

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Area of Science:

  • Oncology
  • Medical Imaging
  • Precision Medicine

Background:

  • Precision medicine aims to tailor treatments to individual patients based on molecular profiles, lifestyle, and environment.
  • Key challenges in implementing precision oncology include identifying predictive biomarkers, understanding tumor heterogeneity, and assessing therapy response early.
  • Resistance to therapies and treatment failures remain significant hurdles in oncology.

Purpose of the Study:

  • To explore the role of PET/computed tomography (PET/CT) in overcoming challenges in precision medicine.
  • To highlight how PET/CT can facilitate the implementation of precision diagnostics and personalized cancer therapies.
  • To demonstrate PET/CT's utility in addressing tumor heterogeneity and early therapy assessment.

Main Methods:

  • Review of current literature on precision medicine and PET/CT applications in oncology.
  • Analysis of how PET/CT addresses biomarker discovery and patient selection.
  • Evaluation of PET/CT's capability in mapping tumor heterogeneity and monitoring treatment response.

Main Results:

  • PET/CT aids in identifying patients who will benefit from specific targeted therapies.
  • The technology assists in visualizing and understanding tumor heterogeneity, a factor in treatment failure.
  • PET/CT enables early assessment of therapy effectiveness and detection of treatment resistance.

Conclusions:

  • PET/computed tomography (PET/CT) is a valuable tool for advancing precision medicine in oncology.
  • PET/CT facilitates crucial aspects of precision oncology, including patient stratification and early treatment evaluation.
  • Integrating PET/CT can significantly improve the delivery and success of personalized cancer treatments.