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Published on: December 16, 2022
Precision Medicine and PET/Computed Tomography: Challenges and Implementation
1Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Department of Biomedical Engineering, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA.
Abstract:
Precision Medicine is about selecting the right therapy for the right patient, at the right time, specific to the molecular targets expressed by disease or tumors, in the context of patient's environment and lifestyle. Some of the challenges for delivery of precision medicine in oncology include biomarkers for patient selection for enrichment-precision diagnostics, mapping out tumor heterogeneity that contributes to therapy failures, and early therapy assessment to identify resistance to therapies. PET/computed tomography offers solutions in these important areas of challenges and facilitates implementation of precision medicine.
Insights
Precision medicine matches therapies to patients using molecular targets. Positron Emission Tomography/computed tomography (PET/CT) addresses challenges in precision oncology, improving patient selection and therapy assessment.
Area of Science:
- Oncology
- Medical Imaging
- Precision Medicine
Background:
- Precision medicine aims to tailor treatments to individual patients based on molecular profiles, lifestyle, and environment.
- Key challenges in implementing precision oncology include identifying predictive biomarkers, understanding tumor heterogeneity, and assessing therapy response early.
- Resistance to therapies and treatment failures remain significant hurdles in oncology.
Purpose of the Study:
- To explore the role of PET/computed tomography (PET/CT) in overcoming challenges in precision medicine.
- To highlight how PET/CT can facilitate the implementation of precision diagnostics and personalized cancer therapies.
- To demonstrate PET/CT's utility in addressing tumor heterogeneity and early therapy assessment.
Main Methods:
- Review of current literature on precision medicine and PET/CT applications in oncology.
- Analysis of how PET/CT addresses biomarker discovery and patient selection.
- Evaluation of PET/CT's capability in mapping tumor heterogeneity and monitoring treatment response.
Main Results:
- PET/CT aids in identifying patients who will benefit from specific targeted therapies.
- The technology assists in visualizing and understanding tumor heterogeneity, a factor in treatment failure.
- PET/CT enables early assessment of therapy effectiveness and detection of treatment resistance.
Conclusions:
- PET/computed tomography (PET/CT) is a valuable tool for advancing precision medicine in oncology.
- PET/CT facilitates crucial aspects of precision oncology, including patient stratification and early treatment evaluation.
- Integrating PET/CT can significantly improve the delivery and success of personalized cancer treatments.
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