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Combinatorial nanodiamond in pharmaceutical and biomedical applications
Dae Gon Lim1, Racelly Ena Prim1, Ki Hyun Kim1
1College of Pharmacy, Dongguk University-Seoul, Gyeonggi, Republic of Korea.
International Journal of Pharmaceutics
|November 20, 2016
Summary
Nanodiamonds (NDs) show promise as drug delivery systems due to their biocompatibility and low toxicity. Their versatile surface chemistry enables complex formation with biomolecules for diverse biomedical applications.
Area of Science:
- Biomedical Engineering
- Pharmaceutical Sciences
- Materials Science
Background:
- Nanodiamonds (NDs) are emerging carbon materials with expanding applications.
- NDs are gaining interest as multifunctional drug delivery platforms.
- NDs exhibit inertness, biocompatibility, and low toxicity, suitable for in vivo use.
Purpose of the Study:
- To review the use of nanodiamonds in biomedical engineering and pharmaceuticals.
- To introduce classified nanodiamond/drug complexes.
- To present potential applications through chemical modification.
Main Methods:
- Literature review of nanodiamond applications in drug delivery.
- Analysis of nanodiamond surface chemistry and complex formation.
- Exploration of chemically modified nanodiamonds for enhanced functionality.
Main Results:
- Nanodiamonds offer versatile surface chemistry for drug complexation.
- Biocompatibility and low toxicity support in vivo applications.
- Chemical modification expands the potential applications of NDs.
Conclusions:
- Nanodiamonds are a promising material for advanced drug delivery systems.
- NDs can be engineered for targeted and combinational therapies.
- Further research into chemically modified NDs will unlock new therapeutic potentials.
