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Thirty years with cyclodextrins.

Dominique Duchêne1, Amélie Bochot1

  • 1Institut Galien Paris-Sud, CNRS UMR 8612, Univ. Paris-Sud, Université Paris-Saclay, 92290 Châtenay-Malabry, France.

International Journal of Pharmaceutics
|November 20, 2016
PubMed
Summary
This summary is machine-generated.

This review highlights thirty years of research on cyclodextrins and their derivatives. These versatile molecules offer adaptable solutions for complex challenges in drug delivery and biomaterials.

Keywords:
Alpha-cyclodextrin (PubChem CID: 444913)BeadsBeta-cyclodextrin (PubChem CID: 444041)CyclodextrinsGamma-cyclodextrin (PubChem CID: 5287407)Hydroxypropyl-beta-cyclodextrin (PubChem CID: 44134771)Hydroxypropyl-gamma-cyclodextrin (PubChem CID: 118705311)InclusionsIndomethacin (PubChem CID: 3715)Isotretinoin (PubChem CID: 5282379)NanoparticlesProgesterone (PubChem CID: 5994)Self-assembling systemsSulfobutylether-beta-cyclodextrin (PubChem CID: 66577045)Tamoxifen citrate (PubChem CID: 2733526)

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Area of Science:

  • Macromolecular science
  • Supramolecular chemistry
  • Materials science

Background:

  • Cyclodextrins (CDs) are cyclic oligosaccharides with unique inclusion properties.
  • Research at Institut Galien Paris-Sud has spanned three decades, focusing on CD applications.
  • CDs offer versatile solutions for complex scientific and technological challenges.

Purpose of the Study:

  • To review thirty years of research on cyclodextrins and their derivatives.
  • To highlight the adaptability and broad applicability of cyclodextrins.
  • To showcase advancements in cyclodextrin-based drug delivery and biomaterials.

Main Methods:

  • Investigation of general characteristics of cyclodextrins and derivatives.
  • Preparation and evaluation of cyclodextrin inclusion complexes.
  • Development of cyclodextrin-based drug delivery systems and nanoparticles.
  • Exploration of cyclodextrins in biomaterial preparation.

Main Results:

  • Established fundamental properties of various cyclodextrins and their derivatives.
  • Demonstrated successful formation and characterization of inclusion complexes.
  • Developed novel drug delivery systems utilizing cyclodextrins.
  • Showcased cyclodextrins as effective components for nanoparticle and biomaterial fabrication.

Conclusions:

  • Cyclodextrins are highly adaptable tools for diverse scientific applications.
  • Decades of research confirm the potential of cyclodextrins in advanced materials and drug delivery.
  • Continued exploration of cyclodextrins promises further innovation in supramolecular chemistry and biomaterials.