Related Experiment Video
Updated: Mar 11, 2026

07:50
Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
Published on: April 18, 2025
1.1K
Systems Approaches to Cancer Biology.
Tenley C Archer1, Elana J Fertig2, Sara J C Gosline3
1Department of Neurology, Boston Children's Hospital, Boston, Massachusetts.
Cancer Research
|November 20, 2016
Summary
Cancer systems biology integrates molecular components to understand cancer complexity. Sharing methods and data is crucial for reproducibility and clinical translation of findings.
Area of Science:
- Cancer Systems Biology
- Interdisciplinary Research
- Computational Biology
Background:
- Cancer is often studied as isolated components, but a systems approach views it as an integrated network.
- Understanding cancer requires combining experimental and computational analyses.
Purpose of the Study:
- To discuss the interdisciplinary field of cancer systems biology.
- To address challenging cancer questions using integrated approaches.
- To foster collaboration and knowledge sharing in cancer research.
Main Methods:
- The Systems Approaches to Cancer Biology Conference brought together researchers.
- Discussions focused on integrating experimental and computational methods.
- Emphasis was placed on interdisciplinary collaboration.
Main Results:
- Elucidating cancer's molecular features reveals significant complexity.
- The field is rapidly advancing through integrated approaches.
- Attendees recognized the need for data and method sharing.
Conclusions:
- Cancer systems biology offers a holistic view of cancer.
- Reproducibility and impact depend on widespread data and method sharing.
- Translating findings to clinical practice is a key goal.
More Related Videos
Related Concept Videos
What is Cancer?
15.3K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
15.3K
Adaptive Mechanisms in Cancer Cells
7.3K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.3K
Adaptive Mechanisms in Cancer Cells
4.2K
4.2K
Cancer
55.3K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
55.3K
Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K

