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Updated: Mar 11, 2026
Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse
Published on: August 15, 2019
Immune-Mediated Protection and Pathogenesis of Chikungunya Virus
Julie M Fox1, Michael S Diamond2,3,4,5
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Abstract:
Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and chronic arthritis. Infection by CHIKV induces a robust immune response that is characterized by production of type I IFNs, recruitment of innate and adaptive immune cells, and development of neutralizing Abs. Despite this response, chronic arthritis can develop in some individuals, which may be due to a failure to eliminate viral RNA and Ag and/or persistent immune responses that cause chronic joint inflammation. In this review, based primarily on advances from recent studies in mice, we discuss the innate and adaptive immune factors that control CHIKV dissemination and clearance or contribute to pathogenesis.
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