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Nitric Oxide and Hydrogen Sulfide Interact When Modulating Gastric Physiological Functions in Rodents
Larisse Tavares Lucetti1, Renan Oliveira Silva1, Ana Paula Macedo Santana1
1Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Digestive Diseases and Sciences
|November 20, 2016
Summary
Nitric oxide (NO) and hydrogen sulfide (H₂S) play interacting roles in gastric function, influencing mucus secretion, blood flow, defense, and motility, but not basal acid secretion.
Area of Science:
- Gastroenterology
- Physiology
- Biochemistry
Background:
- Nitric oxide (NO) and hydrogen sulfide (H₂S) are key signaling molecules in physiological processes.
- Their individual roles in gastric function are established, but their interactions remain less understood.
Purpose of the Study:
- To investigate the effects of NO and H₂S donors on gastric function.
- To explore the potential interactions between NO and H₂S systems in modulating gastric physiology.
Main Methods:
- Mice were administered NO (sodium nitroprusside) and H₂S (sodium hydrosulfite, Lawesson's reagent) donors.
- Gastric secretions, blood flow, mucosal defense against ethanol, and gastric motility were assessed.
- Enzyme expressions (CSE, eNOS) and effects of inhibitors (PAG, L-NAME) were analyzed.
Main Results:
- NO and H₂S donors increased CSE and eNOS expressions, respectively.
- Both donors enhanced mucus production, gastric blood flow, and mucosal defense, with effects reversed by inhibitors.
- NO and H₂S differentially affected gastric emptying and induced relaxation in gastric smooth muscles.
Conclusions:
- NO and H₂S exhibit significant cross-talk in regulating gastric mucus secretion, blood flow, mucosal defense, and motility.
- This interaction is crucial for maintaining gastric homeostasis.
- The interplay does not appear to influence basal gastric acid secretion.
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