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Pathophysiological Mechanisms and Correlates of Therapeutic Pharmacological Interventions in Essential Arterial

Francesco Maranta1, Roberto Spoladore1, Gabriele Fragasso2

  • 1Clinical Cardiology, Heart Failure Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Advances in Experimental Medicine and Biology
|November 20, 2016
PubMed

Insights

Treating arterial hypertension requires managing comorbidities. Antihypertensive drugs should address blood pressure and improve metabolic conditions like diabetes and lipid disorders.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Arterial hypertension (HT) management is complex due to frequent comorbidities and metabolic abnormalities in patients.
  • Choosing antihypertensive medications necessitates considering their impact beyond blood pressure, including effects on metabolic health.

Purpose of the Study:

  • To review pathophysiological mechanisms in essential HT.
  • To analyze pharmacological interventions for HT, focusing on comorbid conditions.

Main Methods:

  • Literature review of pathophysiological mechanisms in essential HT.
  • Analysis of therapeutic pharmacological interventions and their ancillary effects.

Main Results:

  • Hypertensive patients often present with glucose intolerance, lipid disorders, atherosclerosis, and endothelial dysfunction.
  • Drug selection must avoid negative interference with these conditions and ideally offer improvement.

Conclusions:

  • Effective HT treatment involves addressing underlying pathophysiological mechanisms and comorbidities.
  • Pharmacological choices should prioritize agents that positively impact metabolic and vascular health in hypertensive patients.

Keywords:
ACE-inhibitionBeta-blockersHyperglycemiaHypertensionMetabolic syndromePathophysiologyRAAS inhibitionSide effectsTherapyThiazides diuretics

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