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Repigmentation in vitiligo: position paper of the Vitiligo Global Issues Consensus Conference
Emily Y Gan1, Viktoria Eleftheriadou2, Samia Esmat3
1National Skin Centre, Singapore City, Singapore.
Pigment Cell & Melanoma Research
|November 20, 2016
Summary
Repigmentation and maintaining it are key outcomes for vitiligo trials, according to the Vitiligo Global Issues Consensus Conference (VGICC). Success requires over 80% repigmentation and sustained results for six months.
Area of Science:
- Dermatology
- Clinical Trials
- Consensus Development
Background:
- Vitiligo treatment efficacy is often assessed using varied outcome measures.
- Establishing standardized core outcome measures is crucial for comparable vitiligo clinical trials.
Purpose of the Study:
- To define essential core outcome measures for vitiligo clinical trials.
- To establish consensus on repigmentation and its maintenance as key endpoints.
Main Methods:
- International e-Delphi consensus process over three years.
- Review of mechanisms of vitiligo repigmentation.
- Analysis of international meeting discussions and e-surveys.
Main Results:
- 'Repigmentation' and 'maintenance of gained repigmentation' identified as essential core outcome measures.
- Proposed treatment success criteria: >80% repigmentation and >80% maintenance for 6 months.
- Lack of consensus on the optimal measure for assessing target or global repigmentation.
Conclusions:
- The Vitiligo Global Issues Consensus Conference (VGICC) established core outcome measures for vitiligo trials.
- Current limitations in outcome measurement tools necessitate careful selection based on study needs.
- Further workshops are planned to achieve consensus on remaining measurement issues.
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